In investigational TIL cell therapy, a small piece of an individual’s tumor is used to generate billions of rejuvenated TIL in a laboratory1
Tumor tissue procurement
A small portion of the tumor is surgically collected and sent to a specialized laboratory.
The patient’s TIL are separated from other cells in the tumor.
Amplification and reinvigoration
The TIL are rejuvenated and multiplied into the billions.
Infusion of billions of reinvigorated TIL
The multiplied and reenergized TIL are administered back to the patient during a hospital stay.
FDA=Food and Drug Administration; GMP=good manufacturing practice; TIL=tumor infiltrating lymphocytes.
Reference: 1. Wardell S, Lienlaf-Moreno M, Blaskovich M, et al. Iovance Gen 2 TIL manufacturing process produces drug products that exhibit favorable quality attributes for adoptive cell transfer across 5 solid tumor indications. Poster P226 presented at: SITC Annual Meeting; November 6-10, 2019; National Harbor, MD.
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